报告题目： 3D生物打印在组织模型构建上的应用
报告时间： 2019年4月3日（周三） 10：00
报告地点： 苏州大学南校区1号楼3楼骨科研究所317学术报告厅
报告人： 张宇（Yu
Shrike Zhang） 教授
（哈佛大学医学院）
摘要：
Microphysiological systems are microfluidic three-dimensional miniature human tissue and organ models that recapitulate the important biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. These biomimetic microtissues are anticipated to supplement the conventional planar, static cell cultures, and to bridge the gaps between the current pre-clinical animal models and the human body. In addition, multiple microtissues may be channeled together through the microfluidics in a similar manner they arrange in vivo, providing the capacity to analyze interactions among these models. In this talk, I will specifically discuss our recent efforts on developing a series of bioprinting strategies including sacrificial bioprinting, microfluidic bioprinting, and multi-material bioprinting, along with various cytocompatible bioink formulations, for the fabrication of biomimetic 3D tissue models. These platform technologies, when combined with bioreactors and bioanalysis, will likely provide new opportunities in constructing functional tissue and disease models for drug development, therapeutics screening, and precision medicine.
报告人简介：
Prof. Dr. Zhang received a B.Eng. in Biomedical Engineering from Southeast University, China in 2008, after which he then obtained a M.S. in Biomedical Engineering from Washington University in St. Louis (2011) and a Ph.D. in Biomedical Engineering at Georgia Institute of Technology and Emory University School of Medicine (2013). Dr. Zhang pursued his postdoctoral training at Brigham and Women’s Hospital, Harvard Medical School, Harvard-MIT Division of Health Sciences and Technologies, and Wyss Institute for Biologically Inspired Engineering. Dr. Zhang’ research is focused on innovating medical engineering technologies, including 3D bioprinting, organs-on-chips, microfluidics, biomedical imaging, and biosensing, to recreate functional tissues and their biomimetic models. In collaboration with a multidisciplinary team encompassing biomedical, mechanical, electrical, and computer engineers as well as biologists and clinicians, his laboratory seeks to ultimately translate these cutting-edge technologies into the clinics. He has published more than 140 publications in the leading journals including Science, Nature Reviews Materials, Advanced Materials, Biomaterials, Angew Chem, ACS Nano, etc. More information can be found on his website (www.shrikezhang.com).
