Speaker: Professor chen chang

Title: Revising the free radical theory of aging

Time: Wed., Dec. 11, 2019, 15:00pm

Location: 401-1412, Dushu Lake campus

Speaker Biography:

Biography

1986-1990  B.S.,  Nankai University, Tianjin, China

1990-1993  M.S.,  Beijing Normal University, Beijing, China

1993-1996  Ph.D.,  Peking University, Beijing, China

1996-1998  Assistant Professor, Institute of Biophysics, CAS

1998-2000  Associate Professor, Institute of Biophysics, CAS Visiting Scientist in the Institute of Food Research, Norwich, UK (The Royal Society K.C. Wong Research Fellowship)

2000- Principle Investigator (PI) (2004, full professor. Institute of Biophysics, CAS. 2004-2005，Visiting Scientist, Center for Cancer Research, the Medical Research Council, Cambridge, UK)

Research area: Redox, Aging, Traditional Chinese medicine (Nitric oxide and S-nitros(yl)ation and other thiol modification in cellular quality control; redox regulation in aging and the related diseases; mechanism of traditional Chinese medicine). Chen laboratory discovered the important roles of S-nitrosation in protein trafficking, post-translational modification, aging-related cognitive impairment and diseases such as atherosclerosis. They also developed a series of methods for S-nitrosation detection. Their work well demonstrated the specificity and the important signaling roles of redox regulation. She proposed the concept of Precision Redox and Redox-stress Response Capacity (RRC) and has demonstrated the significance of the decay of RRC in aging.

She has been honored National Outstanding Young Scientists and also a receiver of Special Government Allowances of the State Council. She is the Chief Scientist of “National Basic Research Program of China, 973 Program” (2006-2010) and the Chief Scientist of “National Key Research and Development Program of China” (2017-2022). Dr. Chen also serves on the editorial board of Free Radical Research and Redox Biology and the Associate Editor of Free Radical Biology & Medicine.



Papers:

1. Li, J., Zhang, Y., Zhang, Y.Y., Lü, S.L., Miao, Y.T., Yang, J., Huang, S.M., Ma, X.L., Han, L.L., Deng, J.C., Fan, F.F., Liu, B., Huo, Y., Xu, Q.B., Chen, C.*, Wang, X.* & Feng, J.*(2018). GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation. Redox Bio. 17, 386-399.

2. Zhang,Y.Y., Wu, K.Y., Su W.T., Zhang D.F., Wang, P., Qiao, X.H.,, Yao, Q., Yuan,  Z.Q., Yao, Y.G., Liu, G.H., Zhang, C., Liu, L.M. & Chen, C.*(2017). Increased GSNOR expression during aging impairs cognitive function and decreases S-nitrosation of CaMKIIα. J. Neurosci. 37(40):9741-9758.

3. Li, Y.Z., Zhang, Y.Y., Wang, L., Wang, P., Xue Y.H., Li X.P., Qiao, X.H., Zhang, Xu., Xu, T., Liu G.H., Li, P.&Chen,C.*(2017).Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia, Autophagy,13(7):1145-1160.

4. Li, J.M., Gao, Z., Zhao, D., Zhang L.F., Qiao X.H., Zhao Y.Y., Ding, H., Zhang, P.P., Lu, J.Y., Liu, J., Jiang, H.L., Luo, C.* &Chen, C.*(2017). PI-273, a substrate-competitive, specific small molecule inhibitor of PI4KIIα, inhibits the growth of breast cancer cells. Cancer Research. 77(22):6253-6266.

5. Ding, Y.Z., Li, Y.Z., Zhang, X., He, J.L., Lu, D., Fang, X., Wang, Y,C., Wang, J.X., Zhang, Y.Y., Qiao, X.H., Gan, L.M., Chen, C.*& Zhu, Y. *(2017). Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia–reperfusion injury.J Mol Cell Cardiol. 110:70-79.

6. Meng, J., Lv, Z.Y., Qiao, X.H., Li, X.P., Li, Y.Z. &Chen, C.*(2016). The decay of Redox-stress Adaptive Capacity is a substantive characteristic of aging: revising the redox theory of aging. Redox Bio.11,365-374.

7. Zhang, H., Yang, J., Si, W., Gong, W., Chen, C.*& Perrett, S.* (2016). Glutathionylation of DnaK provides a link between oxidative stress and the heat shock response.J. Biol. Chem. 291, 6967-6981.

8. Gao, L., Zhang, Y.Y., Wang Y., Qiao X.H., Zi, J., Chen, C.*& Wan, Y.* (2016) . Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa. Redox Bio. 8, 252–258.

9. Yin, R.Y., Fang, Li., Li, Y.J., Xue P., Li Y.Z., Guan Y.F., Chang Y.S., Chen, C.*& Wang, N.P.* (2015). Pro- inflammatory Macrophages suppress PPARγ activity in Adipocytes via S-nitrosylation. Free Radic. Biol. Med. 89, 895-905.

10. Zhou, Q.J., Li, J.M., Yu, H., Zhai, Y.J., Gao, Z., Liu, Y.X., Pang, X.Y., Zhang, L.F., Schulten, K*., Sun, F*. &Chen, C.* (2014).Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα. Nat. Commun. 5, 35-52.

11. Li, J.M., Zhang, L.F., Gao, Z., Kang, H., Rong, G., &Chen, C.* (2014). Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα and EGFR as anti-tumor strategy. Protein & Cell 5(6), 457-468.

12. Wu, K., Ren, R., Su, W., Wen, B., Zhang, Y., Yi, F., Qiao, X., Yuan, T., Wang, J., Liu, L., Belmonte J.*, Liu, G*. &Chen, C.* (2014). A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. J. Biol. Chem.289, 20193-20199.

13. Mao, K.R., Chen, S.Z., Chen, M.K., Ma, Y.L., Wang, Y., Huang, B., He, Z.Y., Zeng, Y., Hu, Y., Sun, S.H., Li, J., Wu, X.D., Wang, X.R., Strober, W., Chen, C.*,Meng, G.X.* & Sun. B. * (2013). Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res. 23, 201-212.

14. Huang, B. & Chen, C.* (2010). Detection of protein S-Nitrosation using irreversible biotinylation procedures (IBP). Free Radic. Biol. Med.49, 447-456.

15. Li, J.M., Lu, Y., Zhang, J.H., Kang, H., Qin, Z.H.*&Chen, C.* (2010). PI4KIIα is a novel regulator of tumor growth via its action on angiogenesis and HIF-1α regulation. Oncogene 29, 2550-2559.